RESEARCH FOCUS
We are mainly focused on the molecular and cellular mechanisms controlling the proliferation and differentiation of stem cells in the lung and esophagus. We are particularly interested in how these mechanisms operate at different stages of the life, fetal, adolescent, adult, regeneration and aging. A better understanding of these mechanisms will yield important insights into clinical issues that affect millions of people worldwide. The diseases that we are currently modeling include EA/TEF, COVID lung and pulmonary fibrosis.
EA/TEF
The birth defect esophageal atresia with/without tracheoesophageal fistula (EA/TEF) affects 1/2500 newborns. The cause of EA/TEF formation remains unknown and EA/TEF often develops with other complications and birth defects. We have identified Noggin, SOX2 and Isl1 as key regulators of tracheo-esophageal separtion. We are now working other players. Our goal is to generate a list of genes that can be used for prenatal detection of EA/TEF.
Lung Development regeneration, and fibrosis
The interplay of the epithelium and mesenchyme is critical for the morphogenesis of the lung. We found that epithelial signaling proteins (e.g. Wnt) participate in lung regeneration and disease progression. We are now investigating the underlying mechanisms using mouse genetic models and in vitro assays. We hope to find new therapies for promoting lung regeneration and treat diseases like COPD and pulmonary fibrosis.
Upper GI stem cells and diseases
Stem/progenitor cells in the esophagus and stomach are critical for the maintenance of the epithelium which is constantly refreshed. Abnormal proliferation and differentiation of these progenitor cells can lead to diseases in the upper GI. We are interested in the mechanism driving the abnormal commitment of stem/progenitor cells leading to diseases like Barrett's esophagus, eosinophilic esophagitis and cancer.