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PUBLICATIONS     (Pubmed Link)


  1. Li Y, Goldberg EM, Chen X, Xu X, McGuire JT, Leuzzi G, Karagiannis D, Tate T, Farhangdoost N, Horth C, Dai E, Li Z, Zhang Z, Izar B, Que J, Ciccia A, Majewski J, Yoon AJ, Ailles L, Mendelsohn CL, Lu C. Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas.  Mol Cell. 2022 Sep 29:S1097-2765(22)00896-6. doi: 10.1016/j.molcel.2022.09.007. Online ahead of print. PMID: 36206767

  2. Li TW, Kenney AD, Park JG, Fiches GN, Liu H, Zhou D, Biswas A, Zhao W, Que J, Santoso N, Martinez-Sobrido L, Yount JS, Zhu J.SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling. Front Immunol. 2022 Sep 13;13:1007089. doi: 10.3389/fimmu.2022.1007089. eCollection 2022. PMID: 36177032

  3. Huang H, Fang Y, Jiang M, Zhang Y, Biermann J, Melms JC, Danielsson JA, Yang Y, Qiang L, Liu J, Zhou Y, Wang M, Hu Z, Wang TC, Saqi A, Sun J, Matsumoto I, Cardoso WV, Emala CW, Zhu J, Izar B, Mou H, Que J. Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells. Elife. 2022 Sep 21;11:e78217. doi: 10.7554/eLife.78217. PMID: 36129169 Free PMC article. Link

  4. Wei X, Zhang L, Zhang Y, Cooper C, Brewer C, Tsai CF, Wang YT, Glaz M, Wessells HB, Que J, Titus MA, Cirulli V, Glaser A, Liu T, Reder NP, Creighton CJ, Xin L. Ablating Lgr5-expressing prostatic stromal cells activates the ERK-mediated mechanosensory signaling and disrupts prostate tissue homeostasis.Cell Rep. 2022 Sep 6;40(10):111313. doi: 10.1016/j.celrep.2022.111313. PMID: 36070687 Free PMC article.

  5. Ballout F, Lu H, Chen L, Sriramajayam K, Que J, Meng Z, Wang TC, Giordano S, Zaika A, McDonald O, Peng D, El-Rifai W. APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett's-associated esophageal adenocarcinomas. J Exp Clin Cancer Res. 2022 Sep 1;41(1):264. doi: 10.1186/s13046-022-02472-5. PMID: 36045416 Free PMC article.

  6. Palrasu M, Zaika E, Paulrasu K, Caspa Gokulan R, Suarez G, Que J, El-Rifai W, Peek RM Jr, Garcia-Buitrago M, Zaika AI. Helicobacter pylori pathogen inhibits cellular responses to oncogenic stress and apoptosis.PLoS Pathog. 2022 Jun 29;18(6):e1010628. doi: 10.1371/journal.ppat.1010628. eCollection 2022 Jun. PMID: 35767594 Free PMC article.

  7. Chen L, Lu H, Peng D, Cao LL, Ballout F, Srirmajayam K, Chen Z, Bhat A, Wang TC, Capobianco A, Que J, McDonald OG, Zaika A, Zhang S, El-Rifai W. Activation of NOTCH signaling via DLL1 is mediated by APE1-redox-dependent NF-κB activation in oesophageal adenocarcinoma. Gut. 2022 Jun 24:gutjnl-2022-327076. doi: 10.1136/gutjnl-2022-327076. Online ahead of print. PMID: 35750470

  8. Wang Z, Wang J, Zhao H, Zhao T, Chen Y, Jiang M, Zhang S, Wei Y, Zhang J, Zhou Y, Shi S, Fu Z, Yang Y, Zhang Y, Yang L, Que J, Liu K. Targeting the SOX2/PARP1 complex to intervene in the growth of esophageal squamous cell carcinoma. Biomed Pharmacother. 2022 Sep;153:113309. doi: 10.1016/j.biopha.2022.113309. Epub 2022 Jun 20. PMID: 35738180 Free article. Link

  9. Eltobgy MM, Zani A, Kenney AD, Estfanous S, Kim E, Badr A, Carafice C, Daily K, Whitham O, Pietrzak M, Webb A, Kawahara J, Eddy AC, Denz P, Lu M, Kc M, Peeples ME, Li J, Zhu J, Que J, Robinson R, Rosas Mejia O, Rayner RE, Hall-Stoodley L, Seveau S, Gavrilin MA, Zhang X, Thomas J, Kohlmeier JE, Suthar MS, Oltz E, Tedeschi A, Robledo-Avila FH, Partida-Sanchez S, Hemann EA, Abdelrazik E, Forero A, Nimjee SM, Boyaka PN, Cormet-Boyaka E, Yount JS, Amer AO. Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2202012119. doi: 10.1073/pnas.2202012119. Epub 2022 May 19. PMID: 35588457 Free PMC article.

  10. Fang Y, Shao H, Wu Q, Wong NC, Tsong N, Sime P, Que J. Epithelial Wntless (Wls) regulates postnatal alveologenesis. Development. 2021 Dec 21:dev.199505. doi: 10.1242/dev.199505. link



  1. Hayakawa Y, Nakagawa H, Rustgi AK, Que J*, Wang TC*. Stem cells and origins of cancer in the upper gastrointestinal tract. Cell Stem Cell. 2021 Jun 10:S1934-5909(21)00230-7. doi: 10.1016/j.stem.2021.05.012. Online ahead of print. PMID: 34129814. link

  2. Melms JC#, Biermann J#, Huang J#, Wang Y#, Nair A#, Tagore S#, Katsyv I#, Rendeiro AF#, Amin AD#....., Que J*, Izar B*. A molecular single-cell lung atlas of lethal COVID-19. Nature, s41586-021-03569-1 (2021). # Co-first authors,  *Co-corresponding authors. link

  3. Jiang M, Fang Y, Li Y, Huang H, Wei Z, Gao X, Sung H, Hu J, Qiang L, Ruan J, Chen Q,Jiang D, Whitsett J, Ai X, Que J. VEGF receptor 2 (KDR) protects airways from mucus metaplasia through a Sox9 dependent pathway. 2021, Developmental Cell, DOI: 10.1016/j.devcel.2021.04.027. link

  4. Sriramajayam K, Peng D, Lu H, Zhou S, Bhat N, McDonald OG, Que J, Zaika A, El-Rifai W. Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells. Redox Biol. 2021 Apr 19;43:101970. doi: 10.1016/j.redox.2021.101970. Online ahead of print. PMID: 33887608

  5. Zhang Y, Bailey D, Yang P, Kim E, Que J. The development and stem cells of the esophagus.Development. 2021 Mar 29;148(6):dev193839. doi: 10.1242/dev.193839. PMID: 33782045 link

  6. Peng D, Zaika A, Que J, El-Rifai W.The antioxidant response in Barrett's tumorigenesis: A double-edged sword.Redox Biol. 2021 Feb 14;41:101894. doi: 10.1016/j.redox.2021.101894. Online ahead of print. PMID: 33621787


  1. Annavajhala MK, May M, Compres G, Freedberg DE, Graham R, Stump S, Que J, Korem T, Uhlemann AC, Abrams JA. Relationship of the Esophageal Microbiome and Tissue Gene Expression and Links to the Oral Microbiome: A Randomized Clinical Trial. Clin Transl Gastroenterol. 2020 Dec;11(12):e00235. doi: 10.14309/ctg.0000000000000235. PMID: 33512805

  2. Zhu S, Khalafi S, Chen Z, Poveda J, Peng D, Lu H, Soutto M, Que J, Garcia-Buitrago M, Zaika A, El-Rifai W. Silencing of miR490-3p by H. pylori activates DARPP-32 and induces resistance to gefitinib. Cancer Lett. 2020 Oct 28;491:87-96. doi: 10.1016/j.canlet.2020.07.014. Epub 2020 Jul 29. PMID: 32735911

  3. Wang J, Ahimaz PR, Hashemifar S, Khlevner J, Picoraro JA, Middlesworth W, Elfiky MM, Que J, Shen Y, Chung WK. Novel candidate genes in esophageal atresia/tracheoesophageal fistula identified by exome sequencing. Eur J Hum Genet. 2020 Jul 8. doi: 10.1038/s41431-020-0680-2. Online ahead of print. PMID: 32641753

  4. Fang Y, Liu H, Huang H, Li H, Saqi A, Qiang L, Que J. Distinct Stem/Progenitor Cells Proliferate to Regenerate the Trachea, Intrapulmonary Airways and Alveoli of COVID-19 Patients. Cell Research. 2020 Jun 30:1-3. doi: 10.1038/s41422-020-0367-9.

  5. Raad S, David A, Que J, Faure C. Genetic Mouse Models and Induced Pluripotent Stem Cells for Studying Tracheal-Esophageal Separation and Esophageal Development. Stem Cells Dev. 2020 Jul 2. doi: 10.1089/scd.2020.0075.

  6. Karakasheva TA, Kijima T, Shimonosono M, Maekawa H, Sahu V, Gabre JT, Cruz-Acuña R, Giroux V, Sangwan V, Whelan KA, Natsugoe S, Yoon AJ, Philipone E, Klein-Szanto AJ, Ginsberg GG, Falk GW, Abrams JA, Que J, Basu D, Ferri L, Diehl JA, Bass AJ, Wang TC, Rustgi AK, Nakagawa H. Generation and Characterization of Patient-Derived Head and Neck, Oral, and Esophageal Cancer Organoids. Curr Protoc Stem Cell Biol. 2020 Jun;53(1):e109. doi: 10.1002/cpsc.109.

  7. Liu Q, Yu J, Wang L, Tang Y, Zhou Q, Ji S, Wang Y, Santos L, Haeusler RA, Que J, Rajbhandari P, Lei X, Valenti L, Pajvani UB, Qin J, Qiang L. Inhibition of PU.1 ameliorates metabolic dysfunction and non-alcoholic steatohepatitis. J Hepatol. 2020 Mar 2. pii: S0168-8278(20)30124-0. doi: 10.1016/j.jhep.2020.02.025.

  8. Liu K*, Xie F, Zhao T, Zhang R, Gao A, Chen Y, Li H, Zhang S, Xiao Z, Li J, Hong X, Shang L, Huang W, Wang J, El-Rifai W, Zaika A, Chen X, Que J*, Lan X. Targeting SOX2 Protein with Peptide Aptamers for Therapeutic Gains against Esophageal Squamous Cell Carcinoma. Mol Ther. 2020 Mar 4;28(3):901-913. doi: 10.1016/j.ymthe.2020.01.012. Epub 2020 Jan 15. *Co-Corresponding author.


  1. Kim E, Jiang M, Huang H, Zhang Y, Tjota N, Gao X, Robert J, Gilmore N, Gan L, Que J. Isl1 regulation of Nkx2.1 in the early foregut epithelium is required for trachea-esophageal separation and lung lobation. Dev Cell. December 05, 2019 DOI: # Some esophageal epithelial cells are originated from trachea.

  2. Bailey DD, Zhang Y, van Soldt BJ, Jiang M, Suresh S, Nakagawa H, Rustgi AK, Aceves SS, Cardoso WV, Que J. Use of hPSC-derived 3D organoids and mouse genetics to define the roles of YAP in the development of the esophagus. Development. 2019 Nov 20. pii: dev.178855. doi: 10.1242/dev.178855. [Epub ahead of print]

  3. Vanoni S, Zeng C, Marella S, Uddin J, Wu D, Arora K, Ptaschinski C, Que J, Noah T, Waggoner L, Barski A, Kartashov A, Rochman M, Wen T, Martin L, Spence J, Collins M, Mukkada V, Putnam P, Naren A, Chehade M, Rothenberg ME, Hogan SP. Identification of anoctamin 1 (ANO1) as a key driver of esophageal epithelial proliferation in eosinophilic esophagitis. J Allergy Clin Immunol. 2019 Oct 21. pii: S0091-6749(19)31325-9. doi: 10.1016/j.jaci.2019.07.049.

  4. Cheng L, Zhang X, Wang Y, Gan H, Xu X, Lv X, Hua X, Que J, Ordog T, Zhang Z.Chromatin Assembly Factor 1 (CAF-1) facilitates the establishment of facultative heterochromatin during pluripotency exit. Nucleic Acids Res. 2019 Oct 5. pii: gkz858. doi: 10.1093/nar/gkz858. [Epub ahead of print]

  5. Kong W, Hayashi T, Fiches G, Xu Q, Li MZ, Que J, Liu S, Zhang W, Qi J, Santoso N, Elledge SJ, Zhu J. Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions. Genomics Proteomics Bioinformatics. 2019 Jun;17(3):319-331. doi: 10.1016/j.gpb.2018.12.010. Epub 2019 Sep 5.

  6. Huang H, Kong W, Jean M, Fiches G, Zhou D, Hayashi T, Que J, Santoso N, Zhu J. A CRISPR/Cas9 screen identifies the histone demethylase MINA53 as a novel HIV-1 latency-promoting gene (LPG). Nucleic Acids Res. 2019 Jun 5. pii: gkz493. doi: 10.1093/nar/gkz493.

  7. Liu K, Zhao T, Wang J, Chen Y, Zhang R, Lan X, Que J. Etiology, cancer stem cells and potential diagnostic biomarkers for esophageal cancer. Cancer Lett. 2019 May 21;458:21-28. doi: 10.1016/j.canlet.2019.05.018.

  8. Que J, Garman KS, Souza RF, Spechler SJ. Pathogenesis and Cells of Origin of Barrett's Esophagus. Gastroenterology. 2019 May 10. pii: S0016-5085(19)40879-2. doi: 10.1053/j.gastro.2019.03.072. [Epub ahead of print]

  9. Hou Z, Wu Q, Sun X, Chen H, Li Y, Zhang Y, Mori M, Yang Y, Que J*, Jiang M*. Wnt/Fgf crosstalk is required for the specification of basal cells in the trachea. Development. 2019 Jan 29. pii: dev.171496. doi: 10.1242/dev.171496.  * Co-Corresponding author.



  1. Zhang Y, Yang Y, Jiang M, Huang SX, Zhang W, Al Alam D, Danopoulos S, Mori M, Chen YW, Balasubramanian R, Chuva de Sousa Lopes SM, Serra C, Bialecka M, Kim E, Lin S, Toste de Carvalho ALR, Riccio PN, Cardoso WV, Zhang X, Snoeck HW, Que J. 3D modeling of esophageal development using human PSC-derived basal progenitors reveals a critical role for Notch signaling. Cell Stem Cell. 2018 Sep 13. pii: S1934-5909(18)30394-1.

  2. Lin S, Liu K, Zhang Y, Jiang M, Lu R, Folts CJ, Gao X, Noble MD, Zhao T, Zhou Z, Lan X, Que J. Pharmacological Targeting of p38 MAP-Kinase 6 (MAP2K6) Inhibits the Growth of Esophageal Adenocarcinoma. Cell Signal. 2018 Nov;51:222-232. doi: 10.1016/j.cellsig.2018.08.008.

  3. Fang Y, Que J. Notum Balances Wnt Signaling during Tracheal Cartilage Development. Dev Biol. 2018 Feb 21. pii: S0012-1606(18)30130-1. doi: 10.1016/j.ydbio.2018.02.010.



  1. Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H.mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance.Cell Stem Cell. 2017 Dec 7;21(6):806-818.e5. doi: 10.1016/j.stem.2017.11.008.

  2. Natsuizaka M, Whelan KA, Kagawa S, Tanaka K, Giroux V, Chandramouleeswaran PM, Long A, Sahu V, Darling DS, Que J, Yang Y, Katz JP, Wileyto EP, Basu D, Kita Y, Natsugoe S, Naganuma S, Klein-Szanto AJ, Diehl JA, Bass AJ, Wong KK, Rustgi AK, Nakagawa H. "Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma." Nat Commun. 2017 Nov 24;8(1):1758. doi: 10.1038/s41467-017-01500-9.

  3. Jiang M, Li H, Zhang Y, Yang Y, Lu R, Liu K, Lin S, Lan X, Wang H, Wu H, Zhu J, Zhou Z, Xu J, Lee DK, Zhang L, Lee YC, Yuan J, Abrams JA, Wang TC, Sepulveda AR, Wu Q, Chen H, Sun X, She J, Chen X, Que J*. "Transitional basal cells at the squamous-columnar junction generate Barrett's oesophagus." Nature. 2017 Oct 11. doi: 10.1038/nature24269. [Epub ahead of print]

  4. Shi F, Li T, Liu Z, Qu K, Shi C, Li Y, Qin Q, Cheng L, Jin X, Yu T, Di W, Que J, Xia H, She J. "FOXO1: Another avenue for treating digestive malignancy? Semin Cancer Biol. 2017 Sep 28. pii: S1044-579X(17)30183-9. doi: 10.1016/j.semcancer.2017.09.009. [Epub ahead of print] Review.

  5. Spechler SJ, Merchant JL, Wang TC, Chandrasoma P, Fox JG, Genta RM, Goldenring JR, Hayakawa Y, Kuipers EJ, Lund PK, McKeon F, Mills JC, Odze RD, Peek RM Jr, Pham T, Que J, Rustgi AK, Shaheen NJ, Shivdasani RA, Souza RF, Storz P, Todisco A, Wang DH, Wright NA. "A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance". Gastroenterology. 2017 Jul;153(1):e6-e13. doi: 10.1053/j.gastro.2017.05.050. Epub 2017 Jun 3.

  6. Huachao Huang, Shuai Liu, Maxime Jean, Sydney Simpson, He Huang, Mark Merkley, Tsuyoshi Hayashi, Weili Kong, Irene RodriguezSanchez, Hailemichael Yosief, Xiaofeng Zhang, Hongyu Miao, Jianwen Que, James Kobie, James Bradner, Netty Santoso, Wei Zhang, Jian Zhu, Jian Zhu "A Novel Bromodomain Inhibitor Reverses HIV-1 Latency through Specific Binding with BRD4 to Promote Tat and P-TEFb Association" Front. Microbiol., 07 June 2017 |

  7. K. Liu, F. Xie, A. Gao, R. Zhang, X. Zhang, Z. Xiao, Q. Hu, W. Huang, Q. Huang, B. Lin, J. Zhu, H. Wang,  J. Que*, X. Lan*. “SOX2 regulates breast cancer metastasis through miR-181a-5p and miR-30e-5p and their common downstream target TUSC3”. Mol Cancer. 2017 Mar 14;16(1):62. doi: 10.1186/s12943-017-0632-9. *co-corresponding author.

  8. J. Ming, J. Que*. "Re-assessing stem cells in the stomach; one story two tales."  Ann Transl Med. 2017 Feb;5(3):51. doi: 10.21037/atm.2017.01.66. Invited Editorial.

  9. C. Pang, A. LaLonde, T.E. Godfrey, J. Que, Sun, T. Wu, Z. Zhou. "Bile salt receptor TGR5 is highly expressed in esophageal adenocarcinoma and precancerous lesions with significantly worse overall survival and gender differences". Clinical and Experimental Gastroenterology 2017:10 29–37


  1. B. Choy, A.BS. Lalonde, J. Que, T. Wu, Z. Zhou. “MCM4 and MCM7, Potential Novel Proliferation Markers, Significantly Correlated with Ki67, Bmi1, and Cyclin E Expression in Esophageal Adenocarcinoma, Squamous Cell Carcinoma, and Precancerous Lesions”. Hum Pathol. 2016 Nov;57:126-135. doi: 10.1016/j.humpath.2016.07.013.

  2. J.W. Vincentz, J.J. Casasnovas, R.M. Barnes, J. Que , D.E. Clouthier, J. Wang, A.B. Firulli. “Exclusion of Dlx5/6 expression from the distal-most mandibular arches enables BMP-mediated specification of the distal cap”. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7563-8. doi: 10.1073/pnas.1603930113. Epub 2016 Jun 22.PMID:27335460

  3. K. A. Whelan, J. F. Merves, V. Giroux, K. Tanaka, A. Guo, P.M. Chandramouleeswaran, A. J. Benitez, K. Dods, J. Que, J. C. Masterson, Fernando SD, Godwin BC, Klein-Szanto AJ, Chikwava K, Ruchelli ED, Hamilton KE, Muir AB, Wang ML, G.T. Furuta, G.W. Falk, J.M. Spergel,H. Nakagawa. “Autophagy mediates epithelial cytoprotection in eosinophilic oesophagitis”. Gut. 2016 Feb 16. pii: gutjnl-2015-310341. doi: 10.1136/gutjnl-2015-310341.

  4. Y. Zhang, M. Jiang, E. Kim, S. Lin, K. Liu, X. Lan, J. Que *. “Development and stem cells of the esophagus.” Semin Cell Dev Biol. 2016 Dec 19. pii: S1084-9521(16)30482-7. doi: 10.1016/j.semcdb.2016.12.008. *corresponding author.


  1. K. Kawasaki, Kawasaki, M. Watanabe, E. EIdrus, T. Nagai, S. Oommen, T. Maeda, N. Hagiwara, J. Que, P. T. Sharpe, A. Ohazama, “Expression of Sox genes in tooth development”. Int J Dev Biol, 2015;59(10-12):471-8. doi: 10.1387/ijdb.150192ao.

  2. M. Jiang, W.Y. Ku, Z. Zhou, S.E. Dellon, S.G. Falk, H. Nakagawa, M.L. Wang, K. Liu, D.A. Katzka, X.P. Lan, J.H. Peters*, J. Que* “BMP-driven NRF2 activation in basal cell differentiation and Eosinophilic Esophagitis,” J Clin Invest. 2015 Apr 1;125(4):1557-68. doi: 10.1172/JCI78850. Epub 2015 Mar 16. corresponding author.

  3. J. Que *. The Initial Establishment and Epithelial Morphogenesis of the Esophagus: A New Model of Tracheal-Esophageal Separation and Transition of Simple Columnar into Stratified Squamous Epithelium in the Developing Esophagus. WIREs Developmental Biology. Wiley Interdiscip Rev Dev Biol. 2015 Feb 27. doi: 10.1002/wdev.179.


  1. G. Savoy-Burke, F.A. Gilels, W. Pan, D. Pratt, J. Que, L. Gan, P.M. White, A. E. Kiernan, “Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells,” PLoS One. 2014, (9):e108160. doi: 10.1371/journal.pone.0108160. eCollection 2014.

  2. K.C. Liu, B.S. Lin, A.D. Gao, H.Y. Ma, M. Zhao, R. Zhang, H.H. Yan, X.F. Yi, S.J. Lin, J. Que*, X.P. Lan *, “Integrase deficient lentivirus: opportunities and challenges for human gene therapy,” Curr Gene Ther. 2014, 14, 352-364. *co-corresponding author.

  3. Z. Zhou, S. Bandla, J. Ye, Y. Xia, J. Que, J.D. Luketich, A. Pennathur, J.H. Peters, D. Tan, T.E. Godfrey, “Cyclin E involved in early stage carcinogenesis of esophageal adenocarcinoma by SNP DNA microarray and immunohistochemical studies,” BMC Gastroenterol. 2014, 78. doi: 10.1186/1471-230X-14-78. PMCID: PMC3998234.

  4. H. Watanabe, Q. Ma, S. Peng, G. Adelmant, D. Swain, W. Song, C. Fox, J.M. Francis, C.S. Pedamallu, D.S. DeLuca, A.N. Brooks, S. Wang, J. Que, A.K. Rustgi, K.K. Wong, K.L. Ligon, X.S. Liu, J.A. Marto, M. Meyerson, A.J. Bass, “SOX2-p63 interaction and genomic co-localization in squamous cell carcinomas,” J Clin Invest. 2014,1636-1645. doi: 10.1172/JCI71545. PMCID: PMC3973117.


  1. M. Jiang, W.Y. Ku, J. Fu, S. Offermanns, W. Hsu, J. Que*, “Gpr177/mouse Wntless regulates pulmonary vasculature development,” Development. 2013 Sep;140(17):3589-94. PMC- in process. *corresponding author.

  2. K. Liu, B. Lin, M. Zhao, X. Yang, M. Chen, A. Gao, F. Liu, J. Que*, X.P. Lan *, “The multiple roles for Sox2 in stem cell maintenance and tumorigenesis,” Cell Signal. 2013 May;25(5):1264-71. PMCID: PMC3871517.  *co-corresponding author.

  3. K. Liu, M. Jiang, Y. Lu, H. Chen, J. Sun, S. Wu, W.Y. Ku, H. Nakagawa, Y. Kita, S. Natsugoe, J.H. Peters, A. Rustgi, M.W. Onaititis, A. Kiernan, X. Chen, J. Que*, “Sox2 Cooperates with Inflammation-Mediated Stat3 Activation in the Malignant Transformation of Foregut Basal Progenitor Cells,” Cell Stem Cell. 2013, 12, 304-315. PMCID: PMC 3594795. *corresponding author.


  1. H. Chen, J. Li, H. Li, Y. Hu, W. Tevebaugh, M. Yamamoto, J. Que*, X. Chen *, “Transcript profiling identifies dynamic gene expression patterns and an important role for Nrf2/Keap1 pathway in the developing mouse esophagus,” PLoS One. 2012, (5):e36504. PMCID: PMC3342176. *co-correspondent author.

  2. S. Hashimoto, H. Chen, J. Que, B.L. Brockway, J.A. Drake, J.C. Snyder, S.H. Randell, B.R. Stripp, “β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium,” J Cell Sci. 2012 Feb 15;125(Pt 4): 932-942.

  3. I.J. Jacobs, W.Y. Ku, J. Que *, “Genetic and cellular mechanisms regulating anterior foregut and esophageal development,” . Dev Biol. 2012 Sep 1;369(1):54-64.PMCID: PMC3409292. *corresponding author.


  1. M. Rishniw, P. Rodriguez, J. Que*, Z.D. Burke, D. Tosh, H. Chen, X. Chen, “Molecular aspects of esophageal development,” Ann N Y Acad Sci. 2011, 1232, 309-315. *corresponding author.

  2. B. Jovov #, J. Que#G.S. Orlando, Z. Djukic, B.L. Hogan, R.C. Orlando, “Role of E-cadherin in the Pathogenesis of Gastroesophageal Reflux Disease,” Am J Gastroenterol. 2011 Jun;106(6):1039-47. #equal first authorship.

  3. I.J. Jacobs, J. Que *, “Genetic and cellular mechanisms of the formation of esophageal atresia and tracheoesophageal fistula,” Diseases of the Esophagus. 2013, 26(4):356-358. doi: 10.1111/dote.12055. PMCID: in process. *corresponding author


  1. P. Rodriguez, D.S. Silva, Oxburgh L, Wang F, Hogan BL and J. Que*. Bmp signaling in the development of the mouse esophagus and forestomach. Development. 2010, 137, 4171-4176. *corresponding author

  2. J. Romac, M. Ohmuraya, C. Bittner, M.F. Majeed, S.R. Vigna, J. Que, B. Fee, T. Wartmann, K. Yamamura, R.A. Liddle. Transgenic expression of pancreatic secretory trypsin inhibitior-1 rescues SPINK3 deficient mice and restores a normal pancreatic phenotype. Am J Physiol Gastrointest Liver Physiol. 2010 Apr;298(4): G518-24.


  1. G. Li, R. Luo, J. Zhang, K. Yeo, F. Xie, E. Tan, D. Caille, J. Que, Q. Kon, M. Salto-Tellez, P. Meda, S.K. Lim, “Derivation of functional insulin-producing cell lines from primary mouse embryo culture,” Stem Cell Res. 2009 Jan;2(1):29-40. doi: 10.1016/j.scr.2008.07.004.

  2. J. Que, X. Luo, R. Schwartz, B.L. Hogan, “Multiple roles for Sox2 in the developing and adult mouse trachea,” Development. 2009,136, 1899-1907.

  3. J. Que, B. Wilm, H. Hasegawa, F. Wang, D. Bader, B.L. Hogan,  “Contribution of mesothelial cells to vascular smooth muscle and mesenchymal during lung development,”  PNAS. 2008,105,16626-16630.

  4. E.L. Rawlins, T. Okubo, J. Que, Y. Xue, C. Clark, X. Luo, B.L. Hogan, “Epithelial stem/progenitor cells in lung postnatal growth, maintenance, and repair,” Cold Spring Harb Symp Quant Biol. 2008;73:291-5. doi: 10.1101/sqb.2008.73.037.

  5. J. Que #, T. Okubo #, J.R. Goldenring, K.T. Nam, R. Kurotani, E.E. Morrisey, O. Taranova, L.H. Pevny, B.L. Hogan,  “Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm,” Development. 2007,134, 2521-2531. #equal first authorship.

  6. J. Que, Q. Lian, R.M. El Oakley, B. Lim, S.K. Lim, “PI3K/Akt/mTOR-mediated translational control regulates proliferation and differentiation of lineage-restricted RoSH stem cell lines,” J Mol Signal. 2007, 25, 2:9.

  7. J. Que, M. Choi, J.W. Ziel, J. Klingensmith, B.L. Hogan, “Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps,” Differentiation. 2006, 74, 422-437. (Special Issue on organogenesis).

  8. Q. Lian, K. Yeo, J. Que, E. Tan, F. Yu, Y. Yin, M. Salto-Tellez, R.M. Oakley, S.K. Lim, “Establishing clonal cell lines with endothelial-Like potential from CD9, SSEA-1 cells in embryonic stem cell-derived embryoid bodies,” PLoS ONE. 2006, ,1:e6.

  9. J. Que, R. M. El Oakley, M. Salto-Tellez, M. Teh, S.K.Lim, “Co-culture of adult bone marrow cells with embryonic fibroblast feeder cells generates hybrid cell lines with endothelial potential,” In Vitro Cell Dev Biol Anim. 2004, 40,143-149.

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